Tottenham Hotspur have confirmed that Harry Kane has sustained a “significant lateral ligament injury” to his left ankle after limping off against Manchester City.

The England captain underwent a scan on Thursday and the results confirmed the striker is now unlikely to play a part in the remainder of Spurs’ campaign and could be a doubt for England’s two games in the Nations League finals. England will play the Netherlands on 6 June and Kane will have a clearer idea of whether he stands a chance of featuring for the national side after further tests next week.

Kane took six weeks to recover from his previous ankle injury this season but the club painted a bleaker picture with a statement which read: “Following assessment over the past two days, we can confirm that Harry Kane has sustained a significant lateral ligament injury to his left ankle following a challenge in our Champions League quarter-final first-leg win against Manchester City.

“Investigations are ongoing and he will continue to be assessed by our medical staff over the coming week.”

Kane sustained the injury when he went into a strong challenge on Fabian Delph and came off worse. Delph turned on Kane straight away as he felt that the tackle was late and excessive.